Wednesday, May 1, 2019

" Thus, in a normal individual, with say 100 μg/dl serum copper and 30 mg/dl caeruloplasmin, there will be 90 μg bound copper and 10 μg ‘free’ copper.2 Roberts and Schilsky3 give a slightly higher figure for the upper limits of normal as 15 μg/dl and they add that most patients with untreated Wilson disease have 25 μg/dl or above but give no authority for these figures."
" Scheinberg and Sternlieb2 drew attention to this method of estimating ‘free’ serum copper and noted that it was this, ‘diffusible fraction of serum copper that is the ultimate cause of the disease’; and they established the upper limit of normal as 10mg/dl."
'Serum ‘free’ copper in Wilson disease
J.M. WALSHE'
I also found, from the same site/paper/author, J.M. Walshe, this to be of note " However, as stated earlier, ‘free’ copper is really a misnomer as much of the non-caeruloplasmin copper is complexed to albumin and is therefore not available for filtration through a collodion membrane nor is it available for excretion at the glomerulus unless there is significant proteinuria." I don't know exactly what it means, but it would seem to have something to do with a stage of the disease I might be at, where this has yet to occur, although I would be, if I were to continue refraining from taking zinc, theoretically, on the cusp of worsening in this condition eventually.
I also wanted to add that some people have not been diagnosed with Wilson's until they were 70 years of age, I don't know where I heard this, but I know it was from a reliable source, unfortunately I can't keep track of all these, so my being, especially considering how I have halted the progression of the disease, all these years, 36 with the minor amount of scarring to my liver, I just want to be respected, and I want sense to be made by physicians. I don't want to never have the right thing done, and suffer from lack of support and funds, at this point you probably know I believe the psychiatrists are guilty of malpractice, and I don't think it's that complex. It's a weird coincidence that I thought I had this disease, made my points about not caring about the past, what has been done, being repeated, but what makes sense in the future being done, by those who are subject necessarily only to contingent standards, rather than falsely concluding they can fail to respect my intelligence for any number of rationalizations of doing so, and then after not treating myself with zinc, suffering consequences of failing to do so that few, if any, may ever understand, that this described by the early practitioners studying the disease described as 'the ultimate cause of the disease' is elevated, not simply to above normal but above what is described as diagnostic criteria of the disease. So, really, what is correct, plainly, seems to have little to do with my having caught the disease, intelligently, while I am treated like I am raving, on the other hand, by ostensibly responsible persons, early, but why anything has proven I was incorrect, not that it bothered doctors, or that they disagreed, or had different ideas, to feel I was suffering badly enough that zinc should be used, definitely, and therefore, that the disease should be diagnosed also, as those who claimed I didn't have it, were not using the correct definition and understanding of the disease to figure what was correct, who needed some form of treatment for it, and who would not benefit from it.

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